Woodruff School of Mechanical Engineering
Faculty Candidate Seminar
Control of Micro- and Millifluid Dynamics: From Tissue Morphodynamics to Nanomaterial Formulation
Dr. YongTae (Tony) Kim
Massachusetts Institute of Technology
Tuesday, March 12, 2013 at 11:00:00 AM
MRDC Building, Room 4211
The field of system dynamics and controls has made enormous impacts in automotive systems, aerospace, data storage, and robotics, and is now playing similarly transformative roles in addressing important challenges in biology and medicine. Combining dynamics and control technologies with micro- and millifluidic platforms provides unique tools for (1) probing spatiotemporal dynamics in complex biological systems and (2) facilitating the process of synthesizing nanomaterials. This talk will present two examples of such multidisciplinary work. The first example is the investigation of molecular, cellular, and tissue-level dynamics in a Xenopus embryonic tissue in space and time, where our control system accommodates extreme timescales of dynamic response from milliseconds to hours. This study reveals how morphogenetic processes integrate spatiotemporal patterns of stimulation and how intercellular signals are transmitted across multiple cells. The second is the controlled formulation of multifunctional nanomaterials with high productivity and reproducibility, demonstrating an approximately 1000X improvement over previous microfluidic approaches. Our single microfluidic device enables effective assembly of multicomponent nanomaterials including therapeutic and diagnostic lipid-polymer hybrid nanoparticles and high-density lipoprotein-derived nanomaterials. These examples illustrate our approach integrating biology and nanotechnology with system dynamics and controls, which is critical for developing microsystems that mimic the structure and function of human organs and for establishing scale up manufacturing lines of multifunctional nanomaterials for translation of nanomedicines from the lab to the clinic.
Tony Kim is a Postdoctoral Associate at Prof. Robert Langerís group in the David H. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, collaborating with Prof. Zahi Fayad and Prof. Willem Mulder at Mount Sinai School of Medicine and Prof. Omid Farokhzad at Brigham Womenís Hospital and Harvard Medical School. He develops microsystems that mimic vascular endothelial barrier functions for probing the behavior of multifunctional nanomaterials for effective translation of nanomedicines. He also develops automated control system with modular micro/millifluidic chips for multifunctional nanomaterial synthesis and reconstitution with high productivity and reproducibility. In 2011, he received a Ph.D. in Mechanical Engineering from Carnegie Mellon University, where he worked with Prof. William Messner and Prof. Philip LeDuc at Carnegie Mellon University and Prof. Lance Davidson at University of Pittsburgh. His doctorate research focused on developing closed-loop microfluidic control systems for lab-on-a-chip applications to biochemistry and developmental biology. He was a researcher in areas of dynamics, controls, and robotics at R&D Divisions of Hyundai-Kia Motors and Samsung Electronics for 6 years. He received Bachelorís and Masterís degrees in Mechanical and Aerospace Engineering from Seoul National University. He has authored multidisciplinary research articles in major journals including Nano Letters, JACS, PLoS ONE, Lab on a Chip, and IEEE Transactions on Control Systems Technology. He has filed over 20 patent applications worldwide (including 9 US patents), won Dowd-ICES Predoctoral Fellowship and Deanís Fellowship from Carnegie Mellon, and consulted for biomedical companies.
Refreshments will be served.