Woodruff School of Mechanical Engineering
Faculty Candidate Seminar
Proton therapy verification using PET
Dr. Jongmin Cho
Oklahoma State University
Thursday, February 7, 2019 at 11:00:00 AM
Boggs Building, Room 3-47
Dr. C.K. Chris Wang
Proton therapy verification using PET 1) Determination of elemental tissue composition and tumor hypoxic region. In this research, two patients with head-neck cancers were treated using proton therapy and their tissue activation were imaged using an in-room PET scanner. The PET signals were deconvolved to determine the elemental tissue composition. This information can be used to calculate the proton range more accurately and also to determine the tumor hypoxic region. 2) Development of proton activated fiducial markers for in-vivo proton range verification. 18O, 63Cu and 68Zn are strongly activated by low energy protons and decay with positron emissions. These elements were used to develop patient implantable markers which are PET/CT/US/MRI visible. They function as normal radiographic (CT) fiducial markers while providing proton therapy/range verification using PET. Novel brachytherapy using hybrid gold nanoparticles (GNPs) 3) Hybrid GNPs for image-guided radiosensitization and novel brachytherapy. We developed hybrid GNPs emitting positrons, gammas, Cherenkov and NIR (Near Infrared) and function as PET /SPECT/optical image-guided radiosensitizers. Novel HDR brachytherapy using intermediate energy x-ray sources (145Sm and 153Gd) are proposed to treat patients injected with GNPs. Compared with low (e.g., 125I) or high energy (192Ir) brachy sources, the intermediate energy (40 to 100 keV) sources (169Yb ,145Sm and 153Gd) are known to create more Photo- and Auger electrons and ROS for greater radiosensitization.
Dr. Jongmin Cho is a board-certified medical physicist and is currently serving as medical physics program director and assistant professor at Oklahoma State University. Dr. Cho received his PhD in medical physics with collaborative research between the University of Texas MD Anderson Cancer Center and Massachusetts General Hospital. His dissertation is titled 'Proton therapy verification using PET'. In his dissertation, he developed a tomographic reconstruction technique which reveals the elemental tissue compositions of proton patients. Dr. Cho also developed in-vivo proton range verification technique using novel fiducial markers which can be implanted in patients. His research contributes to the proton therapy community with topics ranging from the pre-treatment determination of tumor hypoxic region to post-treatment verification. Prior to his PhD, Dr. Cho worked as a faculty medical physicist at Loma Linda University in California. Dr. Cho has over 10 years of experience with proton therapy. More recently as post-doctoral fellow and assistant professor, Dr. Cho has been investigating on the use of hybrid gold nanoparticles for image-guided radio-sensitization combined with novel brachytherapy.
Refreshments will be served.