Guest Speaker


Digital twins and virtual clinical trials for a multiscale approach to radiation dosimetry.


Dr. Greesham Agasthya


Oakridge, TN


Thursday, January 12, 2023 at 11:00:00 AM   

Where: Building, Room Virtual


Dr. Dan Kotlyar


Multiscale digital twins and virtual clinical trials (VCTs) are versatile tools that can accelerate the study and development of various applications including medical imaging, therapy, and thernostics. Developing digital twins with high-fidelity that can enable large-scale VCTs is challenging and requires interdisciplinary research. VCTs can reduce the parameter search space for clinical trials and make expensive clinical trials significantly efficient. In this talk, I describe the development of a high performance computing (HPC) based digital twin framework to optimize multiscale dosimetry for radiation therapy. All scales between whole-body (organ-level) dose models to single-cell repair mechanism models will be described in the context of radiation therapy. Some challenges and future applications of these multiscale digital twins and VCT frameworks will also be discussed.


Greeshma Agasthya is a research scientist in the Advanced Computing for Health Sciences Section at Oak Ridge National Laboratory. She received her Ph.D. in Biomedical Engineering from Duke University in May 2013 and completed her postdoctoral stint at Emory University’s Winship Cancer Institute in 2015. Her research interests are in medical imaging, theranostics, and modeling and simulation for multiscale radiation dosimetry. She develops and uses multi-scale modeling and simulations of the human body for virtual clinical trials, radiation dosimetry for imaging and therapy, and optimization of medical imaging systems for cancer applications. She works on artificial intelligence (AI) for predicting disease outcomes, and clinical decision support. Throughout her career, she has worked with medical physicists, radiologists, cardiologists, computer engineers, and statisticians to solve healthcare challenges. Greeshma has received grants from DOE, Oak Ridge National Lab, Veterans Affairs, and Cincinnati Children’s Hospital Medical Center.