Woodruff School of Mechanical Engineering
NRE 8011/8012 and MP 6011/6012 Seminar
Nuclear & Radiological Engineering and Medical Physics Programs
Quarter-mm, Quarter-minute & Quarter MBq SPECT and Simultaneous Sub-mm PET-SPECT of molecules, particles and organs in action
Dr. Frederik Beekman
Delft University of Technology / MILabs
Thursday, April 16, 2015 at 11:00:00 AM
Boggs Building, Room 3-47
Dr. Farzad Rahnema
Pivotal questions in pharmacology and biology concern how function of localized cells relates to disease. In experimental neuroscience we have dreamt about a magnifying glass that would allow us to see neurotransmitters in action, in cardiovascular research about a system that would provide us simultaneously with mechanical functions and various cell functions, and in cancer research for simultaneous detailed dynamic distributions of pharmaceuticals and indicators of tumor response. In recent years many groups have been involved in the development of pinhole imaging SPECT systems for imaging rodents. At MILabs and TU-Delft, a line of Ultra-high resolution Single Photon Emission Computed Tomography with integrated X-ray CT (USPECT-CT) has been developed that can quantify tracer dynamics in < quarter mm structures, enable low dose imaging (with fractions of a MBq), or fast dynamic SPECT (<10 s total body) by applying highly advanced multi-pinhole collimators as well as novel image acquisition and reconstruction methods. In addition a device to perform SPECT imaging simultaneous with sub-mm Positron Emission Tomography (PET) was developed. This Versatile Emission Computed Tomography system (dubbed as VECTor) is based on a new clustered multi-pinhole technology and turns also out to enable for the first time high energy SPECT at unprecedented resolution (~0.5mm for I-131). Several scientific results recorded by world wide users of USPECT/CT and VECTor/CT will be shown. Examples include high resolution images of glucose and density and occupancy of transporters/receptors in the brain, extremely detailed imaging of myocardial perfusion, tumor markers, anti-cancer agents (e.g. antibodies) as well as imaging very few cells or particles during a range of points in time. In addition, multimodal platforms including SPECT, PET, MRI, CT, bioluminescence and fluorescence will be discussed.
Prof. Frederik J. Beekman heads the section Radiation, Detection & Medical Imaging at TU Delft University. He co-authored 130 journal papers and is the inventor on 31 patents. Dr. Beekman was honored with several awards for his contributions to SPECT and PET technology and its application in biomedical research. His research interests include radiation technology applied to medicine and biomedical science and image reconstruction from projections. He is an associate editor of several journals and board member of Physics in Medicine & Biology. He is founder and part time officer of MILabs (www.milabs.com) that develops and markets high performance molecular imaging systems.