Woodruff School of Mechanical Engineering
Mechanical Engineering Seminar
Additive Manufacturing in Biomedical Sciences
Dr. Dietmar Hutmacher
Queensland University of Technology
Thursday, September 3, 2015 at 11:00:00 AM
MRDC Building, Room 4211
The application of Additive Biomanufacturing represents one of the most rapidly advancing areas of biomedical sciences in which engineers, scientists and clinicians are contributing en masse to the future of human health care. The combined efforts of a large number of groups around the globe have developed a strong research thrust, which has resulted in a large number of publications. Reviewing this body of literature, there is an increasing trend of research groups inventing their own definitions and terminology, making it difficult to find and compare the results of different research groups. Therefore, to move the field constructively forward it is a conditio sine qua non to clarify various terminologies and standards which are often used interchangeably in the literature. Based on this background, this talk advocates tightening the terminology and has the objective to pen out definitions, which ultimately allow developing an official industry standard term such as ASTM and or ISO for technologies developed for TE/RM. To provide the technological breakthroughs required to establish an innovative additive biomanufacturing (ABM) technology platform, two new manufacturing paradigms need to be addressed, namely “manufacture for design” and “certify-as-you-build”. World-leading fundamental research and advanced science & engineering will be required in order to address the ABM design and fabrication challenge in combination with in situ diagnostics and control of ABM processes by integrating robotics, modelling, sensing, lasers, electronics, optics, and process control. The second part of the talk will present the application of Additive Biomanufacturing which represents one of the most rapidly advancing areas of biomedical sciences in which engineers, scientist and clinicians are contributing in large to the future of human health care and more specifically to the areas of medical devices, tissue engineering & regenerative medicine (TE&RM) and in vitro disease model development. The talk will review the literature and also present the work by the Hutmacher group.
Professor Hutmacher's background is a strong combination of academic and industrial. His expertise is in biomaterials, biomechanics, medical devices and tissue engineering. He is one of the few academics to take a holistic bone engineering concept to clinical application. More than 400 patients have been treated with the FDA-approved bone engineering scaffolds developed by Prof Hutmacher's Singapore-based interdisciplinary research group.Over the last 4 years, Professor Hutmacher has developed an international track record in adult stem cell research related to regenerative medicine. Regenerative medicine/tissue engineering is a rapidly growing multidisciplinary field involving the life, physical and engineering sciences and seeks to develop functional cell, tissue and organ substitutes to repair, replace or enhance biological function that has been lost due to congenital abnormalities, injury, disease or aging. It includes both the regeneration of tissues in vitro for subsequent implantation in vivo as well as regeneration directly in vivo. In addition to having a therapeutic application, tissue engineering can have a diagnostic application where the engineered tissue is used as a biosensor. Engineered tissues can also be used for the development of drugs including screening for novel drug candidates, identifying novel genes as drug targets, and testing for drug metabolism, uptake, and toxicity. Professor Hutmacher's three main areas of research are cartilage, bone graft, and 3D cell cultures.