Title:

Equivalent dose estimation of magnetic hyperthermia and radiation combined approach for quantitative analysis of radiosensitizing effect on prostate cancer cells

Speaker:

Dr. Chulhaeng Huh

Affiliation:

Chief Physicist, Director of Medical Physics Residency program, Augusta University

When:

Thursday, April 13, 2023 at 11:00:00 AM   Add to Calendar

Where:

Boggs Building, Room 3-47

Host:

Farzad Rahnema
farzad@gatech.edu
404.894.3731

Abstract

The aim of this study is quantifying the effectiveness of magnetic hyperthermia and radiation combined therapy by using equivalent radiation dose (EQD) estimation method. The magnetic hyperthermia is a promising method in comparison to conventional hyperthermia because it allows precise control of temperature and localization of heat. Our previous study of Magnetic hyperthermia was conducted in PC3 human prostate cancer cell transplanted mice by implanting the 30nm iron oxide nanoparticle (IONP) into the tumor and it successfully suppressed the tumor size. However, EQD estimation is required to clinical practice of the magnetic hyperthermia in order to implement the radiation as a combined modality in the radiation oncology. Hence, in this study, we calculated EQD in cellular level after magnetic hyperthermia and radiation combined approach and assessed the dose enhancement effect of magnetic hyperthermia. We confirmed the radiation enhancement effect of magnetic hyperthermia by LD50 calculation and EQD estimation. The radioresistant cancer, PC3 showed more sensitive responses to radiation following magnetic hyperthermia than LNCaP, which was 4 to 5 times of dose enhancement ratio in comparison to given radiation doses. In future work, we will also check if there is the dose enhancement effect by the presence of IONP without hyperthermia and it will be carried out either that quantitatively study for differences of radiosensitizing effect between conventional hyperthermia and magnetic hyperthermia.

Biography

Dr. Huh received his PhD in Nuclear Engineering from the University of Florida. He obtained a certificate in the Therapeutic Radiological Physics program from the American Board of Radiology in 2010. He is currently an Assistant Professor in the Medical College of Georgia and works within the Georgia Cancer Center Radiation Therapy facility.

Notes

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