Woodruff School of Mechanical Engineering

NRE 8011/8012 and MP 6011/6012 Seminar

Nuclear & Radiological Engineering and Medical Physics Programs


A New Radiobiological Model Based on Monte Carlo Particle Track Structure


Mr. Brian Lee


Georgia Institute of Technology


Thursday, November 21, 2013 at 11:00:00 AM


Boggs Building, Room 3-47


Dr. C. Wang


Modern radiotherapy techniques are increasingly focused on using heavy particles for the treatment of tumors by making use of the higher relative biological effectiveness (RBE) of high linear energy transfer (LET) particles, including proton therapy in the United States and carbon ion therapy in Japan and Germany. Recent advances in the understanding of cellular DNA have enabled a more clear understanding of how DNA is organized into smaller chromatin domains and chromosomal regions during various cell cycles, allowing for more accurate models to be developed that incorporate the particle track structure to better approximate cell survival. This seminar will cover a Monte-Carlo based nanodosimetric cell model that incorporates particle track structure.


Brian Lee is a third year PhD student in Medical Physics at Georgia Tech working under Dr. Chris Wang. His research emphasis is radiobiological modeling of the cell nucleus using Monte Carlo methods and incorporates Geant4-DNA.