SUBJECT: Ph.D. Dissertation Defense
BY: Nazanin Masoodzadehgan
TIME: Tuesday, July 29, 2014, 3:00 p.m.
PLACE: IBB (Institute of Bioengineering and Biosciences), 1128
TITLE: PET/MR Imaging Of Atherosclerotic Plaque and Tumor Using Dual Modality SPIOs
COMMITTEE: Dr. Gang Bao, Chair (BME)
Dr. Robert Taylor (BME)
Dr. Mark Goodman (Radiology)
Dr. Hui Mao (Radiology)
Dr. Yongjian Liu (Radiology)
Dr. Farzad Rahnema (NRE/MP)


Early stage disease diagnosis still remains a challenge despite much efforts to develop novel imaging and diagnostic techniques. Nanoparticles used as a molecular imaging contrast agents with multifunctionality and flexibility provide a platform for targeting the specific disease biomarkers and integration of imaging modalities. In this work, we investigated the potential of the radiolabeled, targeted super paramagnetic iron oxide nanoparticles (SPIOs) in imaging atherosclerotic plaque and tumor in vivo using magnetic resonance imaging (MRI) and Positron emission tomography (PET).