SUMMARY

In this work, a fluid-structure interaction model based on lattice Boltzmann method is developed to study the role that lymphatic valves and vessels play in the lymphatic pumping performance. First, the effects of lymphatic valve properties such as valve aspect ratios, bending stiffness, in-plane stiffness, and dynamic flow conditions on pumping performance are studied. Physiologically relevant vessel contraction is also analyzed to evaluate the lymphatic pumping against adverse pressure gradient under varied valve and vessel parameters. Furthermore, a filarial worm is studied in the context of the lymphatic system to examine the behavior of such worms in the lymphatic system. The findings identified optimal parameters for the lymphatic system leading to efficient pumping under a larger range of adverse pressure gradient. This work elucidates crucial parameters of the lymphatic system that enable efficient operation and provide insights into conditions leading to lymphatic disorders.