|SUBJECT:||M.S. Thesis Presentation|
|TIME:||Wednesday, June 25, 2014, 3:00 p.m.|
|PLACE:||Whitaker Ford Building, 1214|
|TITLE:||Dynamics of composite beads in optical tweezers and their application to study of HIV cell entry.|
|COMMITTEE:||Dr. Cheng Zhu, Chair (ME)
Dr. Susan Thomas (ME)
Dr. Evan Evans (BME)
In this thesis we report a novel symmetry breaking system in single-beam optical trap. The breaking of symmetry is observed in Brownian dynamics of a linked pair of beads with substantially differing radii (500nm and 100nm). Such composite beads were originally conceived as a manipulation means to study of Brownian interactions between mesoscopic biological agents of the order of 100 – 200 nm (viruses or bacteria) with cell surfaces. During the initial testing of the composite bead system, we discovered that the system displayed thermally activated transitions and energetics of symmetry breaking. This thesis, while making a brief overview of the biological relevance of the composite bead system, focuses primarily on the analysis and experimentation that reveals the complex dynamics observed in the system.