SUMMARY

Compared with commercial dual-energy computed tomography (DECT) solutions, beam modulation is an economical and efficient alternative to achieve single-scan DECT which can be enabled with conventional diagnostic or cone-beam CT machines. Existing beam modulation methods employ regularization strategy for DECT reconstruction, which cannot handle the half-fan and the short-scan mode due to inevitable data loss in each spectrum. Besides, all previous works employ primary-modulation scheme, leading to magnified penumbra area in the detector side. In this dissertation, a novel static detector modulation system is designed to realize dual-energy projection acquisition during a single scan. Then the detector-modulated projection data is fed into the pre-trained pix2pix GAN model to generate full-sampled datasets at high- and low-energy spectra. DECT reconstruction and material decomposition can be subsequently implemented using the synthesized complete dual-energy data.