The Woodruff School

SUMMARY

The development of new tools for the modeling and simulation of radiation damage to DNA and the resulting chromosome aberrations has enabled the analysis of cell survival characteristics to be performed via computer simulation. By combining TOPAS brachytherapy modeling, rapid SDD generating code, and MEDRAS analysis, rapid calculations of DNA double strand breaks, chromosome aberrations, and cell survival curves for brachytherapy sources is demonstrated and compared with various in vitro studies found in the literature.

SUBJECT:	Ph.D. Proposal Presentation

BY:	Joseph Dick

TIME:	Tuesday, May 28, 2024, 9:30 a.m.

PLACE:	Boggs, 3-47

TITLE:	Fast Monte Carlo Cell-by-Cell Simulation of Radiation-Induced DNA Damage, Chromosome Aberrations, and Cell Death for Low-Dose-Rate Brachyhterapy Sources

COMMITTEE:	Dr. C-K Chris Wang, Chair (NRE/MP) Dr. Steve Biegalski (NRE/MP) Dr. Anna Erickson (NRE/MP) Dr. Shaheen Dewji (NRE/MP) Dr. Eric Elder (Emory, Radiation Oncology)

SUMMARY The development of new tools for the modeling and simulation of radiation damage to DNA and the resulting chromosome aberrations has enabled the analysis of cell survival characteristics to be performed via computer simulation. By combining TOPAS brachytherapy modeling, rapid SDD generating code, and MEDRAS analysis, rapid calculations of DNA double strand breaks, chromosome aberrations, and cell survival curves for brachytherapy sources is demonstrated and compared with various in vitro studies found in the literature.