SUMMARY
Polydimethylsiloxane (PDMS) based microfluidic devices contain micro-scale channels used for routing fluids in bio-chemical analysis. The existing methods for producing such microfluidic devices are highly labor intensive and require expensive materials and processes. An alternative approach is to use a machined metal mold for curing the PDMS layers, which are then assembled into a device. This thesis developed innovative methods for robotic de-bonding and peeling of cured PDMS layers from a machined aluminum mold.