The Woodruff School

SUMMARY

Link:
https://bluejeans.com/9482907093/

Summary:
A stroke has structural, physiological and behavioral consequences that significantly impact one’s quality of life. Previously, the term lesion after stroke denoted that impacted tissue was completely and irrevocably non-functional. However, improving imaging techniques, such as the novel approach Tissue Integrity Gradation via T2w T1w Ratio(TIGR), developed by Dr. Lisa Krishnamurthy, has made it possible to characterize gradients in degree of post-stroke structural damage with surviving tissue, offering new targets for rehabilitation; however, it must be verified with a physiological quantity such as Cerebral Blood Flow (CBF). In this work, we examine data evaluating the relationship between tissue integrity and blood flow within the lesion, and their combined impact on functional behavioral outcomes after stroke. Ultimately, we intend show that the lesion may still contain viable tissue with neural substrates that can potentially be engaged with rehabilitation.

SUBJECT:	M.S. Thesis Presentation

BY:	Clara Glassman

TIME:	Wednesday, June 23, 2021, 11:00 a.m.

PLACE:	Virtual Room, Virtual

TITLE:	BLOOD FLOW IN CHRONIC STROKE LESIONS: AN IMPROVED MODEL OFBRAIN-BEHAVIOR RELATIONSHIPS

COMMITTEE:	Dr. C. K. Wang, Co-Chair (NRE) Dr. Lisa Krishnamurthy, Co-Chair (VA) Dr. Keith McGregor (VA) Dr. Tianye Niu (NRE)

SUMMARY Link: https://bluejeans.com/9482907093/ Summary: A stroke has structural, physiological and behavioral consequences that significantly impact one’s quality of life. Previously, the term lesion after stroke denoted that impacted tissue was completely and irrevocably non-functional. However, improving imaging techniques, such as the novel approach Tissue Integrity Gradation via T2w T1w Ratio(TIGR), developed by Dr. Lisa Krishnamurthy, has made it possible to characterize gradients in degree of post-stroke structural damage with surviving tissue, offering new targets for rehabilitation; however, it must be verified with a physiological quantity such as Cerebral Blood Flow (CBF). In this work, we examine data evaluating the relationship between tissue integrity and blood flow within the lesion, and their combined impact on functional behavioral outcomes after stroke. Ultimately, we intend show that the lesion may still contain viable tissue with neural substrates that can potentially be engaged with rehabilitation.